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miércoles, 22 de abril de 2015

Margaret G. Spinelli

Dear friends,

This week, I would like to change our work method and give the responsibility of diagnosis to all you. I hope you enjoy playing doctors!

I present you Mrs. A, a 34-year-old married mother. I want you to read down her story, which was studied by Margaret G. Spinelli, and write a clinical comment.

You could name her symptoms one by one and, considering her particular context, find out a diagnosis. If you can add more information about it etiology, management or treatment don’t be shy and explain us, it will be really interesting!

I am going to analyze this case in detail in my conclusion so don’t forget to come back in four or five days to check your answers.

Good luck and have fun, doctors!


María Lamana Villegas



Mrs. A, a 34-year-old married mother who lived with her husband and their 5-year-old daughter, strangled her infant son to death 3 weeks after birth. She had a planned, healthy pregnancy with some depression at 28 weeks’ gestation. She had a normal spontaneous vaginal delivery, giving birth to a healthy boy, “B.” She began breastfeeding immediately. From postpartum days 2 through 11, her depression worsened. She was unable to sleep but could not get out of bed or attend to her hygiene. She was suspicious that her husband would harm B. On postpartum day 2, she began having obsessional, ego-dystonic images of throwing B out the window. She believed, despite the pediatrician’s reassurances, that she was harming B with her breast milk and that he was losing weight. She was unable to give him a bath, believing that he had “gas” or “something bad” inside and could not be moved.
On day 12, while alone in the car with B, she thought of killing herself and the baby, although “at the time I don’t think I had any idea why.” On day 13, she attempted suicide by overdose. She slept through the night and did not report the suicide attempt to anyone. She abruptly weaned B and then became disorganized and confused, unsure of what formula and size and types of bottles and nipples to use. She was agitated, calling friends day and night for opinions. On day 15 she attempted to smother B with a towel. “I don’t believe it was a thought,” she said. “It was ‘autopilot.’” Her husband came upstairs, and Mrs. A believes that his presence shook her out of the “state” she was in. “I did not have the compulsion to hurt him any more after that evening … I just thought something was wrong, and I wasn’t thinking straight.” Her husband knew that she was not herself, but he did not understand that she was depressed and psychotic. Mrs. A did not receive treatment for her illness.
On postpartum day 20, Mrs. A awoke at 6:30 a.m. to feed B when he cried. Her husband and daughter kissed her goodbye, and Mr. A walked their daughter to school before going to work. She soon felt as if she was “taken over.” She describes a dazed, trance-like state with confusion: “Something internal like a force … it was not a voice … but I did not have control. It was an instant. I don’t recall thinking anything … I had no feelings. It was happening but I wasn’t there.… At the time, nothing came into my head saying, ‘No, do not do this.’ … My inside was gone and it was something else.” She briefly placed a towel over B’s nose and mouth, but stopped. The “force” then became intense. She placed a washcloth in B’s mouth and then strangled him with a telephone cord. She felt she was not connected to her own hands. When B was dead, she washed him with a cloth, removed the remnants of his umbilical cord, changed his diaper, and left the room. She went into the bathroom, where she made an unsuccessful attempt to cut her wrists.
Mrs. A was charged with homicide and was incarcerated. She described her psychiatric history as “moody” with cycling states, every 3 days, of jocularity, creativity, and high energy alternating with an irritable, withdrawn mood and tearfulness. She had two previous episodes of major depression, including a postpartum depression after the birth of her daughter that was associated with ego-dystonic images of throwing her daughter against a wall or hitting her with a hammer. She denied psychotic thoughts. The depression resolved in 6 months without treatment. She was a successful “supermom” with her daughter and was an energetic worker in her job.
Mrs. A’s mother has a diagnosis of bipolar disorder, which worsened after the birth her second child. She had multiple psychiatric hospitalizations for psychotic episodes with chronic paranoia and grandiose, volatile moods.





9 comentarios:

  1. Hi Maria, I found interesting your idea of challenging us to solve this clinical case also relates to a theme we have very present in our minds because we examined recently of Psychiatry.

    The postpartum period is a biological, psychological and social changes. This is considered the most vulnerable time for the occurrence of psychiatric disorders such as postpartum dysphoria, postpartum depression and postpartum psychosis.

    The postpartum dysphoria is a frame is light and transient and requires no treatment. Postpartum depression prevails, can cause negative effects on mother-infant interaction and other aspects of women's lives and should be treated. Postpartum psychosis is characterized by a severe condition that involves psychotic and affective symptoms with risk of suicide and infanticide and usually requiring hospitalization. Anxiety disorders can be exacerbated or precipitated postpartum, especially generalized anxiety disorder, post-traumatic stress disorder and obsessive-compulsive disorder.

    In this case I think this patient experienced a brief psychotic disorder postpartum possibly associated to a base of bipolar disorder, since it is the most associated with postpartum psychosis and she has family history.

    I think that mental disorders in the postpartum period have clinical peculiarities that deserve attention from clinicians and researchers.

    Joana Gonçalves

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  2. Hi Maria,
    Thank you for this challenge I think it was very original. After carefully reading the case of Mrs. A, and having considered her symptoms and history, I have concluded that the patient may suffer from postpartum psychosis since:
    It is a rare disorder that arises recently after giving birth (usually two to three weeks after). This matches the case of our patient.
    Mrs. A had a healthy pregnancy, but at 28 weeks of gestation, presented a bit of depression, which became more severe after delivery. Other signs and symptoms that make us suspect that our diagnosis is correct is that the patient suffers from insomnia, and is unable to get out of bed to wash. She also suffers from hallucinations, ego-dystonic obsessive images and periods of delusions and obsessions.
    It also reinforces our suspicion, the fact that the patient has suffered from major depression, and her mother was diagnosed with bipolar disorder. Both are risk factors for developing postpartum psychosis.
    It is very important that this disease is diagnosed as early as possible, since postpartum psychosis has a 5% rate of suicide and a 4% rate of infanticide.
    The problem is that it is often confused with postpartum depression.

    Dunia Jové

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  3. Hi Dr. Lamana! :D

    I really like your idea of changing the method.

    Attending to the case, this patient is likely to have bipolar disease.
    She presents with fatigue, insomnia and depressive mood, which make us think of a depression. Concretely, it appears after giving birth to a child, so it's a postpartum depression. As far as I'm concern, postpartum depression is related to bipolar disease.
    Moreover, she describes her psychiatric history as “moody” with cycling states (including episodes of major depression), what really fits with bipolar diagnosis. This disease also appears in her family history, which supports even more that diagnosis. Actually, bipolar disease it's the second most inheritable mental disorder with a 70% of inheritability.
    In severe grades of affective disease, like the one you've explained, psychotic symptoms may appear. That's why the patient explains she can see strange images or have weird thoughts.

    Can't wait to check if I'm right. :P


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  4. Hi María, thank you for this article, I really enjoy reading it since recently we have studied this subject, so we may be able to have an idea of what this women can have.

    As we all know, the postpartum period is the moment of mayor risk for a women to develop an affective disorder. This basically happens because of the rapid hormone changes. The postpartum psychiatric illness can be divided in three groups (in order of severity): postpartum blues, postpartum depression and postpartum psychosis. So these three categories should be included in the list of possible diagnosis.

    The clinic presented by the women include basically: insomnia, delusional beliefs (thoughts that his husband want to harm B or that she was harming B giving him breast milk), ego-dystrionic images and cycling mood states every 3 days. The symptoms appeared in the second day and became worst the next days. Also, eventhough she had a healthy pregnancy, during the 28 week she had a depression. Finally, attending to her family, is important to take into account that her mother had a bipolar disorder.

    With this, I think the women may have a postpartum psychosis, which occurs during the first month of the postpartum period. So, it can be define as a brief psychotic disorder. However, since her mother had a bipolar disorder, she had a depression during pregnancy and cycling mood during the postpartum period; I can also think that this postpartum psychosis may represent an episode of bipolar illness, been his period that maniac episode.

    Elisa Salazar

    PD: I like this new idea of posting a clinical case :)

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  5. Hi Dra. Lamana. Thank you for encouraging us to make a diagnosis of this clinical case.

    As my colleagues said, the postpartum period is a moment in women’s life with a high risk for developing affective disorders.

    Referring to the case, the patient suffers from insomnia, hallucinations, ego-dystonic obsessive images and periods of delusions and obsessions. Also this patient has a family history of affective disorders. For these reasons, we should suspect of a postpartum depression.
    Moreover, this patient describes a psychiatric history with cycling states with episodes of major depression, so we could suspect also of a bipolar disease.

    With this suspects I think the patient has an affective disease, in particular bipolar disease with could be associated with postpartum depression.

    I can’t wait to know if I’m right with the diagnosis.

    Mercè

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  6. Hi Maria!

    We thank something new on the blog and I think trying to diagnose a mental illness is a great idea since we have recently now for having recently psychiatry test.

    I think Mrs. A suffers a bipolar disorder with psychotic episodes.
    Bipolar disorder has maniac and depressive phases and stages.
    Mrs. A has already had depressions in which she felt tired, not out of bed and had deterioration of personal hygiene. Also she attempted suicide twice.
    Of the maniac phase doesn’t talk, probably because she doesn’t consider it as a bad thing. However she tells all about the psychotic process that led to strangle her baby, impulses that she felt and he could not control the unjustified belief that her husband was going to do something bad to her son and also hallucinations.

    I hope I have not gone far for the diagnosis!

    Marta Córdoba Calonge

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  7. Your idea for the blog is really original Lamana, I like this change.
    The truth is that it is a very interesting topic because it is a disease more common than we think. Around 80% of women present the mild postpartum depression during the postpartum period. It appears around the third day after birth and usually lasts until about four weeks. Postpartum major depression (PPD) can appear between 4 and 30 weeks postpartum with more pronounced symptoms.
    In this case the patient shows insomnia, hallucinations, ego-dystonic obsessive images and periods of delusions and obsessions. She had a depression at the 28 week and it is important to take into account that her mother had a bipolar disorder.
    By the symptoms I consider the patient suffers postpartum psychosis is probably an episode of bipolar illness.
    Postpartum psychosis is misdiagnosed or confused with postpartum depression; if not undergo any treatment psychosis may result in tragic consequences. Postpartum psychosis has a 5% rate of suicide and a 4% rate of infanticide.
    So we must consider this disease to diagnose it on time and not get to have serious consequences.

    Andrea García Gómez

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  8. Hi Maria! I love this new way of working in this blog and becoming doctors for a moment.
    I fins this case very interesting and I thing you this woman has a postpartum psychosis because the clinic is similar to typical manic symptoms, such as euphoria, overactivity, decreased sleep requirement, loquaciousness, flight of ideas, increased sociability, disinhibition, irritability, violence and delusions, which are usually grandiose or religious in content; on the whole these symptoms are more severe than in mania occurring at other times, with highly disorganized speech and extreme excitement.
    I've been searching about this disease and I found something I didn't know which is that without treatment, these psychoses can last many months; but with modern therapy they usually resolve within a few weeks. Mothers who suffer a puerperal episode are liable to other manic depressive or acute polymorphic episodes, some of which occur after other children are born, some during pregnancy or after an abortion, and some unrelated to childbearing.

    Claudia Bosch

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  9. CONCLUSION

    Most of you have found out the specific diagnosis, so first of all I would like to congratulate all you!


    As it has been said, Mrs. A suffers from postpartum psychosis, which is a manifestation of a lifetime vulnerability to affective disorders with childbirth as the precipitating factor.

    The prevalence of postpartum psychosis in the general population is 1–2 per 1,000 childbirths, and the rate is 100 times higher in women with bipolar disorder.

    For any mother who presents with a postpartum mood disorder, the clinician must inquire about thoughts of harming herself or the infant and determine whether infanticidal thoughts are obsessional or psychotic.

    Finally, about the treatment and management of these kind of patients I have to say Postpartum psychosis is a psychiatric emergency. Inpatient psychiatric treatment is essential to ensure the safety of mother and baby. After a physical examination is performed, metabolic causes must be ruled out. Treatment should be guided by the symptom profile. Acute treatment involves the use of mood stabilizers, antipsychotics, and benzodiazepines. Insomnia should be treated aggressively. Antidepressants should be avoided because they may induce rapid cycling or mixed states.

    That's all for today, I think you have enough information about this special psychiatric illness. I'm glad to know you like this new working method and you enjoy becoming doctors for a moment!

    Thank you,
    María Lamana Villegas.

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